Three new aaptamine derivatives from the South China Sea sponge Aaptos aaptos.
J Asian Nat Prod Res
; 17(12): 1231-8, 2015.
Article
em En
| MEDLINE
| ID: mdl-26699877
ABSTRACT
Three new aaptamine derivatives (1-3), together with six known related compounds (4-9), have been isolated from the South China Sea sponge Aaptos aaptos. The structures of all compounds were unambiguously elucidated on the basis of spectroscopic analyses. Compounds 1, 4, 5, 7, and 9 showed cytotoxic activities against HeLa, K562, MCF-7, and U937 cell lines with IC50 values in the range of 0.90-12.32 µM.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Poríferos
/
Naftiridinas
/
Antineoplásicos
Limite:
Animals
/
Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article