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Deficiency of intestinal mucin-2 protects mice from diet-induced fatty liver disease and obesity.
Hartmann, Phillipp; Seebauer, Caroline T; Mazagova, Magdalena; Horvath, Angela; Wang, Lirui; Llorente, Cristina; Varki, Nissi M; Brandl, Katharina; Ho, Samuel B; Schnabl, Bernd.
Afiliação
  • Hartmann P; Department of Medicine, University of California San Diego, La Jolla, California;
  • Seebauer CT; Department of Medicine, University of California San Diego, La Jolla, California;
  • Mazagova M; Department of Medicine, University of California San Diego, La Jolla, California;
  • Horvath A; Department of Medicine, University of California San Diego, La Jolla, California;
  • Wang L; Department of Medicine, University of California San Diego, La Jolla, California; Department of Medicine, VA San Diego Healthcare System, San Diego, California;
  • Llorente C; Department of Medicine, University of California San Diego, La Jolla, California; Department of Medicine, VA San Diego Healthcare System, San Diego, California;
  • Varki NM; Department of Medicine, University of California San Diego, La Jolla, California; Department of Pathology, University of California San Diego, La Jolla, California; and.
  • Brandl K; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California.
  • Ho SB; Department of Medicine, University of California San Diego, La Jolla, California; Department of Medicine, VA San Diego Healthcare System, San Diego, California;
  • Schnabl B; Department of Medicine, University of California San Diego, La Jolla, California; Department of Medicine, VA San Diego Healthcare System, San Diego, California; beschnabl@ucsd.edu.
Am J Physiol Gastrointest Liver Physiol ; 310(5): G310-22, 2016 Mar 01.
Article em En | MEDLINE | ID: mdl-26702135
Nonalcoholic fatty liver disease (NAFLD) and obesity are characterized by altered gut microbiota, inflammation, and gut barrier dysfunction. Here, we investigated the role of mucin-2 (Muc2) as the major component of the intestinal mucus layer in the development of fatty liver disease and obesity. We studied experimental fatty liver disease and obesity induced by feeding wild-type and Muc2-knockout mice a high-fat diet (HFD) for 16 wk. Muc2 deficiency protected mice from HFD-induced fatty liver disease and obesity. Compared with wild-type mice, after a 16-wk HFD, Muc2-knockout mice exhibited better glucose homeostasis, reduced inflammation, and upregulated expression of genes involved in lipolysis and fatty acid ß-oxidation in white adipose tissue. Compared with wild-type mice that were fed the HFD as well, Muc2-knockout mice also displayed higher intestinal and plasma levels of IL-22 and higher intestinal levels of the IL-22 target genes Reg3b and Reg3g. Our findings indicate that absence of the intestinal mucus layer activates the mucosal immune system. Higher IL-22 levels protect mice from diet-induced features of the metabolic syndrome.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interleucinas / Endotoxinas / Mucina-2 / Hepatopatia Gordurosa não Alcoólica / Microbioma Gastrointestinal / Inflamação / Mucosa Intestinal / Obesidade Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interleucinas / Endotoxinas / Mucina-2 / Hepatopatia Gordurosa não Alcoólica / Microbioma Gastrointestinal / Inflamação / Mucosa Intestinal / Obesidade Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article