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Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.
Laukka, Tuomas; Mariani, Christopher J; Ihantola, Tuukka; Cao, John Z; Hokkanen, Juho; Kaelin, William G; Godley, Lucy A; Koivunen, Peppi.
Afiliação
  • Laukka T; From the Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, FIN-90014 Oulu, Finland.
  • Mariani CJ; the Department of Medicine, Section of Hematology/Oncology, the Committee on Molecular Pathogenesis and Molecular Medicine and.
  • Ihantola T; From the Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, FIN-90014 Oulu, Finland.
  • Cao JZ; the Department of Medicine, Section of Hematology/Oncology, the Committee on Cancer Biology, University of Chicago, Chicago, Illinois 60637.
  • Hokkanen J; Admescope Ltd., Typpitie 1, FIN-90620 Oulu, Finland.
  • Kaelin WG; the Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts 02215, and the Howard Hughes Medical Institute, Chevy Chase, Maryland 20815.
  • Godley LA; the Department of Medicine, Section of Hematology/Oncology, the Committee on Cancer Biology, University of Chicago, Chicago, Illinois 60637.
  • Koivunen P; From the Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, FIN-90014 Oulu, Finland, peppi.koivunen@oulu.fi.
J Biol Chem ; 291(8): 4256-65, 2016 Feb 19.
Article em En | MEDLINE | ID: mdl-26703470
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Regulação Neoplásica da Expressão Gênica / Proteínas Proto-Oncogênicas / Ácido Succínico / Dioxigenases / Proteínas de Ligação a DNA / Fumaratos / Neuroblastoma Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Regulação Neoplásica da Expressão Gênica / Proteínas Proto-Oncogênicas / Ácido Succínico / Dioxigenases / Proteínas de Ligação a DNA / Fumaratos / Neuroblastoma Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article