The frequency of HLA alleles in the Romanian population.
Immunogenetics
; 68(3): 167-78, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26711124
ABSTRACT
Knowledge of human leukocyte antigen (HLA) allele frequencies is essential for bone marrow and kidney donor searches. The Romanian Caucasian population is heterogeneous and information on HLA polymorphism has not been well studied. We characterized the HLA genetic profile and allele frequencies of regional populations in Romania. HLA-A, B and DRB1 alleles were examined in 8252 individuals, belonging to the four main regions of Romania. The most common alleles found in the Romanian population are the following HLA-A*01, A*02, A*03, A*11, A*24; HLA-B*18, B*35, B*44, B*51 and HLA-DRB1*01, DRB1*03, DRB1*07, DRB1*11, DRB1*13, DRB1*15, DRB1*16. More than half of the alleles are non-homogeneously spread in Romania. These results provide a starting point for future analyses of genetic heterogeneity in Romania.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Alelos
/
Frequência do Gene
/
Genética Populacional
/
Antígenos HLA
Limite:
Humans
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article