Evaluation of cytochrome P450 inductions by anti-epileptic drug oxcarbazepine, 10-hydroxyoxcarbazepine, and carbamazepine using human hepatocytes and HepaRG cells.

Sugiyama, Ikuo; Murayama, Norie; Kuroki, Ayaka; Kota, Jagannath; Iwano, Shunsuke; Yamazaki, Hiroshi; Hirota, Takashi

Sugiyama, Ikuo; Murayama, Norie; Kuroki, Ayaka; Kota, Jagannath; Iwano, Shunsuke; Yamazaki, Hiroshi; Hirota, Takashi.

Afiliação

Sugiyama I; a Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences , Tokyo University of Science , Chiba , Japan .
Murayama N; b Drug Metabolism and Pharmacokinetics, Novartis Pharma K.K. , Tokyo , Japan .
Kuroki A; c Laboratory of Drug Metabolism and Pharmacokinetics , Showa Pharmaceutical University , Tokyo , Japan , and.
Kota J; a Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences , Tokyo University of Science , Chiba , Japan .
Iwano S; d Drug Metabolism and Pharmacokinetics, Novartis Institutes for Biomedical Research , Hyderabad , Andhra Pradesh , India.
Yamazaki H; b Drug Metabolism and Pharmacokinetics, Novartis Pharma K.K. , Tokyo , Japan .
Hirota T; c Laboratory of Drug Metabolism and Pharmacokinetics , Showa Pharmaceutical University , Tokyo , Japan , and.

Xenobiotica ; 46(9): 765-74, 2016 Sep.

Article em En | MEDLINE | ID: mdl-26711482

Assuntos

Carbamazepina/análogos & derivados; Carbamazepina/farmacologia; Indutores das Enzimas do Citocromo P-450/farmacologia; Linhagem Celular Tumoral; Citocromo P-450 CYP2B6/metabolismo; Sistema Enzimático do Citocromo P-450/metabolismo; Humanos; Oxcarbazepina; RNA Mensageiro/metabolismo

Palavras-chave

Anti-epileptic drug; auto-induction; carbamazepine; in vitro; induction; oxcarbazepine

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carbamazepina / Indutores das Enzimas do Citocromo P-450 Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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