Gamma glutamyltransferase, inflammation and cardiovascular risk factors in isolated coronary artery ectasia.
Rev Port Cardiol
; 35(1): 33-9, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-26711537
ABSTRACT
INTRODUCTION AND OBJECTIVE:
There are conflicting data on the prevalence of cardiovascular risk factors in coronary artery ectasia (CAE). It is unclear whether CAE is associated with high-sensitivity C-reactive protein (hs-CRP) and gamma glutamyltransferase (GGT). We therefore investigated major cardiovascular risk factors, serum GGT and hs-CRP levels in a large population of patients with CAE.METHODS:
A total of 167 patients with isolated CAE and 150 controls with normal coronary arteries were selected from 10505 patients undergoing coronary angiography. Serum GGT and hs-CRP levels were evaluated in addition to cardiovascular risk factors including family history, obesity, smoking, diabetes, hypertension and hyperlipidemia.RESULTS:
Hypertension and obesity were slightly more prevalent in CAE patients than in controls, whereas diabetes was slightly less frequent in CAE patients. Other risk factors were similar. Serum GGT (22 [17-42] vs. 16 [13-21] U/l, p=0.001) and hs-CRP (2.9 [1.9-3.6] vs. 1.4 [1.1-1.8] mg/l, p=0.001) levels were higher in CAE patients than in controls. The presence of CAE was independently associated with diabetes (OR 0.44, 95% CI 0.20-0.95, p=0.04), obesity (OR 2.84, 95% CI 1.07-7.56, p=0.04), GGT (OR 1.08, 95% CI 1.03-1.12, p=0.001) and hs-CRP levels (OR 3.1, 95% CI 2.1-4.6, p=0.001). In addition, GGT and hs-CRP levels were higher in diffuse and multivessel ectasia subgroups than focal and single-vessel ectasia subgroups (each p<0.05).CONCLUSIONS:
Our findings show that CAE can be independently and positively associated with obesity, GGT and hs-CRP levels, but inversely with diabetes. Moreover, its severity may be related to GGT and hs-CRP levels.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Proteína C-Reativa
/
Doenças Cardiovasculares
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Gama-Glutamiltransferase
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Inflamação
Tipo de estudo:
Etiology_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article