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Histone deacetylase activity and recurrent bacterial bronchitis in severe eosinophilic asthma.
Zuccaro, L; Cox, A; Pray, C; Radford, K; Novakowski, K; Dorrington, M; Surette, M G; Bowdish, D; Nair, P.
Afiliação
  • Zuccaro L; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
  • Cox A; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
  • Pray C; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
  • Radford K; Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
  • Novakowski K; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
  • Dorrington M; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
  • Surette MG; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
  • Bowdish D; Division of Gastroenterology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
  • Nair P; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
Allergy ; 71(4): 571-5, 2016 Apr.
Article em En | MEDLINE | ID: mdl-26715426
ABSTRACT
An increase in P13 Kinase activity and an associated reduction in histone deacetylase activity may contribute to both relative steroid insensitivity in patients with severe eosinophilic asthma and impaired macrophage scavenger function and susceptibility to recurrent infective bronchitis that may, in turn, contribute to further steroid insensitivity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Asma / Infecções Bacterianas / Bronquite Tipo de estudo: Diagnostic_studies Limite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Asma / Infecções Bacterianas / Bronquite Tipo de estudo: Diagnostic_studies Limite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article