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Total Synthesis of Gelsenicine via a Catalyzed Cycloisomerization Strategy.
Newcomb, Eric T; Knutson, Phil C; Pedersen, Blaine A; Ferreira, Eric M.
Afiliação
  • Newcomb ET; Department of Chemistry, University of Georgia , Athens, Georgia 30602, United States.
  • Knutson PC; Department of Chemistry, University of Georgia , Athens, Georgia 30602, United States.
  • Pedersen BA; Department of Chemistry, University of Georgia , Athens, Georgia 30602, United States.
  • Ferreira EM; Department of Chemistry, University of Georgia , Athens, Georgia 30602, United States.
J Am Chem Soc ; 138(1): 108-11, 2016 Jan 13.
Article em En | MEDLINE | ID: mdl-26716762
ABSTRACT
The first total synthesis of (±)-gelsenicine is reported. The synthetic route is highly efficient (13 steps), featuring (1) a pivotal metal-catalyzed isomerization/rearrangement process that forges the central core of the molecule and (2) two facile C-N bond-forming steps that establish the flanking heterocycles.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alcaloides Indólicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alcaloides Indólicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article