Total Synthesis of Gelsenicine via a Catalyzed Cycloisomerization Strategy.
J Am Chem Soc
; 138(1): 108-11, 2016 Jan 13.
Article
em En
| MEDLINE
| ID: mdl-26716762
ABSTRACT
The first total synthesis of (±)-gelsenicine is reported. The synthetic route is highly efficient (13 steps), featuring (1) a pivotal metal-catalyzed isomerization/rearrangement process that forges the central core of the molecule and (2) two facile C-N bond-forming steps that establish the flanking heterocycles.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Alcaloides Indólicos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article