Noradrenaline increases intracellular glutathione in human astrocytoma U-251 MG cells by inducing glutamate-cysteine ligase protein via ß3-adrenoceptor stimulation.

Yoshioka, Yasuhiro; Kadoi, Hisatsugu; Yamamuro, Akiko; Ishimaru, Yuki; Maeda, Sadaaki

Yoshioka, Yasuhiro; Kadoi, Hisatsugu; Yamamuro, Akiko; Ishimaru, Yuki; Maeda, Sadaaki.

Afiliação

Yoshioka Y; Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. Electronic address: yoshioka@pharm.setsunan.ac.jp.
Kadoi H; Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. Electronic address: 12d404kh@edu.setsunan.ac.jp.
Yamamuro A; Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. Electronic address: yamamuro@pharm.setsunan.ac.jp.
Ishimaru Y; Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. Electronic address: ishimaru@pharm.setsunan.ac.jp.
Maeda S; Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. Electronic address: smaeda@pharm.setsunan.ac.jp.

Eur J Pharmacol ; 772: 51-61, 2016 Feb 05.

Article em En | MEDLINE | ID: mdl-26724392

Assuntos

Astrocitoma/patologia; Glutamato-Cisteína Ligase/metabolismo; Glutationa/metabolismo; Espaço Intracelular/efeitos dos fármacos; Espaço Intracelular/metabolismo; Norepinefrina/farmacologia; Receptores Adrenérgicos beta 3/metabolismo; Antagonistas de Receptores Adrenérgicos beta 3/farmacologia; Linhagem Celular Tumoral; Regulação Enzimológica da Expressão Gênica/efeitos dos fármacos; Humanos

Palavras-chave

Astrocytes; Atenolol (PubChem CID: 2249); Butoxamine (PubChem CID: 134495); CL316243 (PubChem CID: 5312115); Glutamate-cysteine ligase; Glutathione; Isoproterenol (PubChem CID: 3779); Noradrenaline; Noradrenaline (PubChem CID: 439260); PD98059 (PubChem CID: 4713); Phenoxybenzamine (PubChem CID: 4768); Propranolol (PubChem CID: 4946); SP600125 (PubChem CID: 8515); SR59230A (PubChem CID: 5311452); ß(3)-adrenoceptor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Astrocitoma / Norepinefrina / Receptores Adrenérgicos beta 3 / Espaço Intracelular / Glutamato-Cisteína Ligase / Glutationa Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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