Modelling of the nonlinear end-systolic pressure-volume relation and volume-at-zero-pressure in porcine experiments.
Annu Int Conf IEEE Eng Med Biol Soc
; 2015: 6544-7, 2015.
Article
em En
| MEDLINE
| ID: mdl-26737792
ABSTRACT
The End-Systolic Pressure-Volume Relation (ESPVR) is generally modelled as a linear relationship between P and V as cardiac reflexes, such as the baroreflex, are typically suppressed in experiments. However, ESPVR has been observed to behave in a curvilinear fashion when cardiac reflexes are not suppressed, suggesting the curvilinear function may be more clinically appropriate. Data was gathered from 41 vena cava occlusion manoeuvres performed experimentally at a variety of PEEPs across 6 porcine specimens, and ESPVR determined for each pig. An exponential model of ESPVR was found to provide a higher correlation coefficient than a linear model in 6 out of 7 cases, and a lower Akaike Information Criterion (AIC) value in all cases. Further, the exponential ESPVR provided positive V0 values in a physiological range in 6 out of 7 cases analysed, while the linear ESPVR produced positive V0 values in only 3 out of 7 cases, suggesting linear extrapolation of ESPVR to determine V0 may be flawed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Volume Sistólico
/
Pressão Sanguínea
/
Modelos Cardiovasculares
/
Contração Miocárdica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article