Nitric Oxide Inhibitory Activity and Absolute Configurations of Arylalkenyl α,ß-Unsaturated δ/γ-Lactones from Cryptocarya concinna.
J Nat Prod
; 79(1): 196-203, 2016 Jan 22.
Article
em En
| MEDLINE
| ID: mdl-26741483
ABSTRACT
During an ongoing exploration of potential anti-inflammatory agents from medicinal plants, eight new arylalkenyl α,ß-unsaturated δ-lactones, cryptoconcatones A-H (1-8), and two unusual arylalkenyl α,ß-unsaturated γ-lactones, cryptoconcatones I and J (9 and 10), were identified from the leaves and twigs of Cryptocarya concinna. The structures of these compounds were established based on spectroscopic data (MS, 1D/2D NMR), and their absolute configurations were determined with Riguera's method, the modified Mosher's method, chemical derivatization, and the Snatzke chirality rule. Compounds 4-6 and 8-10 showed inhibitory activity toward nitric oxide (NO) production in lipopolysaccharide-induced RAW 264.7 macrophages, particularly compounds 4 and 8-10, with IC50 values of 3.2, 4.2, 3.4, and 7.5 µM, respectively.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Cryptocarya
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Lactonas
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Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article