New Phragmalin-Type Limonoids from Chukrasia tabularis and Their α-Glucosidase Inhibitory Activity.
Molecules
; 21(1): 58, 2016 Jan 05.
Article
em En
| MEDLINE
| ID: mdl-26742029
ABSTRACT
Phytochemical investigation on the stems of C. tabularis led to the isolation of five new phragmalin-type limonoids and six known ones. The structures of the new compounds 1-5, named chukbularisins A-E, were elucidated by spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR) and comparisons with published data. All the compounds were evaluated for in vitro α-glucosidase inhibitory activity. Compounds 2, 3, 4, 5, and 8 exhibited inhibitory activity against α-glucosidase with IC50 values of 0.06 ± 0.008, 0.04 ± 0.002, 0.52 ± 0.039, 1.09 ± 0.040, and 0.20 ± 0.057 mM, respectively (using acarbose as positive control, IC50 0.95 ± 0.092 mM).
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Base de dados:
MEDLINE
Assunto principal:
Meliaceae
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Limoninas
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Inibidores Enzimáticos
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Alfa-Glucosidases
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article