Effects of thiazide diuretic on vascular eicosanoid system of spontaneously hypertensive rats.
J Hypertens
; 7(6): 493-9, 1989 Jun.
Article
em En
| MEDLINE
| ID: mdl-2674278
ABSTRACT
To assess the role of the vascular eicosanoid system in thiazide therapy, we examined the aortic eicosanoid system of spontaneously hypertensive rats (SHR) treated with trichloromethiazide for 2 weeks. The blood pressure reduction caused by the thiazide treatment was associated with a significant decrease in vascular vasodepressor prostacyclin (PGI2) generation, whereas neither nifedipine nor captopril treatment lowered vascular PGI2 generation. The thiazide diuretic directly lowered PGI2 synthase activity in cultured vascular smooth muscle cells (VSMC), thereby decreasing PGI2 generation in the VSMC and probably in the aortic wall. This direct inhibitory effect on vascular PGI2 generation was not observed with either furosemide or indapamide. Thus, vascular PGI2 generation is reduced with trichloromethiazide, partly through its direct inhibition of PGI2 synthase; this has possible relevance to the non-beneficial effects of thiazide diuretics on the vascular sclerotic changes.
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Base de dados:
MEDLINE
Assunto principal:
Epoprostenol
/
Oxirredutases Intramoleculares
/
Sistema Enzimático do Citocromo P-450
/
Inibidores de Simportadores de Cloreto de Sódio
/
Hipertensão
/
Isomerases
/
Músculo Liso Vascular
Limite:
Animals
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article