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Patterns of Radiation-Associated Lymphopenia in Children with Cancer.
Miljkovic, Milos D; Grossman, Stuart A; Ye, Xiaobu; Ellsworth, Susannah; Terezakis, Stephanie.
Afiliação
  • Miljkovic MD; a Medical Oncology Service , National Cancer Institute , Bethesda , Maryland , USA.
  • Grossman SA; b Department of Medical Oncology.
  • Ye X; b Department of Medical Oncology.
  • Ellsworth S; c Department of Radiation Oncology , Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins , Baltimore , Maryland , USA.
  • Terezakis S; c Department of Radiation Oncology , Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins , Baltimore , Maryland , USA.
Cancer Invest ; 34(1): 32-8, 2016.
Article em En | MEDLINE | ID: mdl-26745229
Adults with cancer commonly develop severe lymphopenia two months following chemoradiation therapy, which is an independent predictor of survival. In this retrospective study of 53 children with central nervous system tumors and sarcomas, the frequency, severity, and duration of radiation-associated lymphopenia was similar to that seen in adults. Pretreatment lymphocyte counts were 1,000 cells/mm(3) or greater in all patients, with 66% experiencing grade III-IV lymphopenia two months after chemoradiation. Lymphocyte counts remained significantly lower than baseline 12 months later. Further studies are needed to determine if this is also associated with poorer survival, as seen in adults.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Radioterapia / Linfopenia / Neoplasias Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Radioterapia / Linfopenia / Neoplasias Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article