[Strategies for biobank networks. Classification of different approaches for locating samples and an outlook on the future within the BBMRI-ERIC]. / Strategien zur Vernetzung von Biobanken. Klassifizierung verschiedener Ansätze zur Probensuche und Ausblick auf die Zukunft in der BBMRI-ERIC.

ABSTRACT

BACKGROUND: Medical research projects often require more biological material than can be supplied by a single biobank. For this reason, a multitude of strategies support locating potential research partners with matching material without requiring centralization of sample storage. OBJECTIVES: Classification of different strategies for biobank networks, in particular for locating suitable samples. Description of an IT infrastructure combining these strategies. MATERIALS AND METHODS: Existing strategies can be classified according to three criteria (a) granularity of sample data coarse bank-level data (catalogue) vs. fine-granular sample-level data, (b) location of sample data central (central search service) vs. decentral storage (federated search services), and (c) level of automation automatic (query-based, federated search service) vs. semi-automatic (inquiry-based, decentral search). All mentioned search services require data integration. Metadata help to overcome semantic heterogeneity. RESULTS: The "Common Service IT" in BBMRI-ERIC (Biobanking and BioMolecular Resources Research Infrastructure) unites a catalogue, the decentral search and metadata in an integrated platform. As a result, researchers receive versatile tools to search suitable biomaterial, while biobanks retain a high degree of data sovereignty. CONCLUSIONS: Despite their differences, the presented strategies for biobank networks do not rule each other out but can complement and even benefit from each other.