Your browser doesn't support javascript.
loading
Sex-specific genetic determinants for arterial stiffness in Dahl salt-sensitive hypertensive rats.
Decano, Julius L; Pasion, Khristine A; Black, Nicole; Giordano, Nicholas J; Herrera, Victoria L; Ruiz-Opazo, Nelson.
Afiliação
  • Decano JL; Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, 700 Albany Street, W-609, Boston, MA, 02118, USA. Julius113@gmail.com.
  • Pasion KA; Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, 700 Albany Street, W-609, Boston, MA, 02118, USA. kapasion@bu.edu.
  • Black N; Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, 700 Albany Street, W-609, Boston, MA, 02118, USA. nlblack@bu.edu.
  • Giordano NJ; Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, 700 Albany Street, W-609, Boston, MA, 02118, USA. Giordano@bu.edu.
  • Herrera VL; Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, 700 Albany Street, W-609, Boston, MA, 02118, USA. vherrera@bu.edu.
  • Ruiz-Opazo N; Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, 700 Albany Street, W-609, Boston, MA, 02118, USA. nruizo@bu.edu.
BMC Genet ; 17: 19, 2016 Jan 11.
Article em En | MEDLINE | ID: mdl-26754450
BACKGROUND: Arterial stiffness is an independent predictor of cardiovascular outcomes in hypertensive patients including myocardial infarction, fatal stroke, cerebral micro-bleeds which predicts cerebral hemorrhage in hypertensive patients, as well as progression to hypertension in non-hypertensive subjects. The association between arterial stiffness and various cardiovascular outcomes (coronary heart disease, stroke) remains after adjusting for age, sex, blood pressure, body mass index and other known predictors of cardiovascular disease, suggesting that arterial stiffness, measured via carotid-femoral pulse wave velocity, has a better predictive value than each of these factors. Recent evidence shows that arterial stiffening precedes the onset of high blood pressure; however their molecular genetic relationship (s) and sex-specific determinants remain uncertain. We investigated whether distinct or shared genetic determinants might underlie susceptibility to arterial stiffening in male and female Dahl salt-sensitive rats. Thus, we performed a genome-wide scan for quantitative trait loci (QTLs) affecting arterial stiffness in six-week old F2 (Dahl S x R)-intercross male and female rats characterized for abdominal aortic pulse wave velocity and aortic strain by high-resolution ultrasonography. RESULTS: We detected five highly significant QTLs affecting aortic stiffness: two interacting QTLs (AS-m1 on chromosome 4 and AS-m2 on chromosome16, LOD 8.8) in males and two distinct interacting QTLs (AS-f1 on chromosome 9 and AS-f2 on chromosome11, LOD 8.9) in females affecting pulse wave velocity. One QTL (AS-1 on chromosome 3, LOD 4.3) was found to influence aortic strain in a sex-independent manner. None of these arterial stiffness QTLs co-localized with previously reported blood pressure QTLs detected in equivalent genetic intercrosses. CONCLUSIONS: These data reveal sex-specific genetic determinants for aortic pulse wave velocity and suggest distinct polygenic susceptibility for arterial stiffness and salt-sensitive hypertension in Dahl rats based upon reported blood pressure QTLs in equivalent (Dahl S x R)-intercrosses.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Caracteres Sexuais / Rigidez Vascular / Hipertensão Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Caracteres Sexuais / Rigidez Vascular / Hipertensão Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article