Synthesis of 8-heteroaryl nitroxoline analogues via one-pot sequential Pd-catalyzed coupling reactions.
Org Biomol Chem
; 14(6): 1969-81, 2016 Feb 14.
Article
em En
| MEDLINE
| ID: mdl-26754567
ABSTRACT
A series of 8-heteroaryl substituted quinolines were prepared, either by direct C-H arylation of five-membered heteroarenes, or Pd-catalyzed coupling of organoboron reagents with bromoquinolines. The use of (benzo)thiophenyl or (benzo)furanyl boron coupling partners allowed further C-H functionalization on the five-membered heteroaryl ring with aryl bromides in one flask to access a variety of polyconjugated molecular architectures. The developed methodology represents a simple approach towards 8-arylated analogues of the biologically interesting nitroxoline core.
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1
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
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Paládio
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Nitroquinolinas
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article