Model assessment in dynamic treatment regimen estimation via double robustness.
Biometrics
; 72(3): 855-64, 2016 09.
Article
em En
| MEDLINE
| ID: mdl-26756122
ABSTRACT
Dynamic treatment regimens (DTRs) recommend treatments based on evolving subject-level data. The optimal DTR is that which maximizes expected patient outcome and as such its identification is of primary interest in the personalized medicine setting. When analyzing data from observational studies using semi-parametric approaches, there are two primary components which can be modeled the expected level of treatment and the expected outcome for a patient given their other covariates. In an effort to offer greater flexibility, the so-called doubly robust methods have been developed which offer consistent parameter estimators as long as at least one of these two models is correctly specified. However, in practice it can be difficult to be confident if this is the case. Using G-estimation as our example method, we demonstrate how the property of double robustness itself can be used to provide evidence that a specified model is or is not correct. This approach is illustrated through simulation studies as well as data from the Multicenter AIDS Cohort Study.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Terapêutica
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Modelos Estatísticos
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Medicina de Precisão
Tipo de estudo:
Clinical_trials
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Humans
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Male
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article