Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes.

Walker, Olivia S; Elsässer, Simon J; Mahesh, Mohan; Bachman, Martin; Balasubramanian, Shankar; Chin, Jason W

Walker, Olivia S; Elsässer, Simon J; Mahesh, Mohan; Bachman, Martin; Balasubramanian, Shankar; Chin, Jason W.

Afiliação

Walker OS; Medical Research Council Laboratory of Molecular Biology , Francis Crick Avenue, Cambridge CB2 0QH, United Kingdom.
Elsässer SJ; Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom.
Mahesh M; Medical Research Council Laboratory of Molecular Biology , Francis Crick Avenue, Cambridge CB2 0QH, United Kingdom.
Bachman M; Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom.
Balasubramanian S; Medical Research Council Laboratory of Molecular Biology , Francis Crick Avenue, Cambridge CB2 0QH, United Kingdom.
Chin JW; Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom.

J Am Chem Soc ; 138(3): 718-21, 2016 Jan 27.

Article em En | MEDLINE | ID: mdl-26761588

Assuntos

Epigênese Genética/genética; Isocitrato Desidrogenase/genética; Isocitrato Desidrogenase/metabolismo; Proteínas Mutantes/metabolismo; Neoplasias/genética; Neoplasias/metabolismo; Processos Fotoquímicos; Arginina/metabolismo; Células HEK293; Humanos; Isocitrato Desidrogenase/química; Modelos Moleculares; Estrutura Molecular; Proteínas Mutantes/genética; Mutação; Neoplasias/enzimologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Epigênese Genética / Proteínas Mutantes / Processos Fotoquímicos / Isocitrato Desidrogenase / Neoplasias Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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