Your browser doesn't support javascript.
loading
Brain volumetric changes and cognitive ageing during the eighth decade of life.
Ritchie, Stuart J; Dickie, David Alexander; Cox, Simon R; Valdes Hernandez, Maria Del C; Corley, Janie; Royle, Natalie A; Pattie, Alison; Aribisala, Benjamin S; Redmond, Paul; Muñoz Maniega, Susana; Taylor, Adele M; Sibbett, Ruth; Gow, Alan J; Starr, John M; Bastin, Mark E; Wardlaw, Joanna M; Deary, Ian J.
Afiliação
  • Ritchie SJ; Department of Psychology, the University of Edinburgh, Edinburgh, EH8 9JZ, United Kingdom.
  • Dickie DA; Centre for Cognitive Ageing and Cognitive Epidemiology, the University of Edinburgh, Edinburgh, EH8 9JZ, United Kingdom.
  • Cox SR; Neuroimaging Sciences, Brain Research Imaging Centre, the University of Edinburgh, Edinburgh, EH4 2XU, United Kingdom.
  • Valdes Hernandez Mdel C; Scottish Imaging Network, a Platform for Scientific Excellence (SINAPSE) Collaboration.
  • Corley J; Centre for Clinical Brain Sciences, the University of Edinburgh, Edinburgh, EH16 4TJ, United Kingdom.
  • Royle NA; Department of Psychology, the University of Edinburgh, Edinburgh, EH8 9JZ, United Kingdom.
  • Pattie A; Centre for Cognitive Ageing and Cognitive Epidemiology, the University of Edinburgh, Edinburgh, EH8 9JZ, United Kingdom.
  • Aribisala BS; Centre for Cognitive Ageing and Cognitive Epidemiology, the University of Edinburgh, Edinburgh, EH8 9JZ, United Kingdom.
  • Redmond P; Neuroimaging Sciences, Brain Research Imaging Centre, the University of Edinburgh, Edinburgh, EH4 2XU, United Kingdom.
  • Muñoz Maniega S; Scottish Imaging Network, a Platform for Scientific Excellence (SINAPSE) Collaboration.
  • Taylor AM; Centre for Clinical Brain Sciences, the University of Edinburgh, Edinburgh, EH16 4TJ, United Kingdom.
  • Sibbett R; Department of Psychology, the University of Edinburgh, Edinburgh, EH8 9JZ, United Kingdom.
  • Gow AJ; Centre for Cognitive Ageing and Cognitive Epidemiology, the University of Edinburgh, Edinburgh, EH8 9JZ, United Kingdom.
  • Starr JM; Neuroimaging Sciences, Brain Research Imaging Centre, the University of Edinburgh, Edinburgh, EH4 2XU, United Kingdom.
  • Bastin ME; Scottish Imaging Network, a Platform for Scientific Excellence (SINAPSE) Collaboration.
  • Wardlaw JM; Centre for Clinical Brain Sciences, the University of Edinburgh, Edinburgh, EH16 4TJ, United Kingdom.
  • Deary IJ; Department of Psychology, the University of Edinburgh, Edinburgh, EH8 9JZ, United Kingdom.
Hum Brain Mapp ; 36(12): 4910-25, 2015 Dec.
Article em En | MEDLINE | ID: mdl-26769551
Later-life changes in brain tissue volumes--decreases in the volume of healthy grey and white matter and increases in the volume of white matter hyperintensities (WMH)--are strong candidates to explain some of the variation in ageing-related cognitive decline. We assessed fluid intelligence, memory, processing speed, and brain volumes (from structural MRI) at mean age 73 years, and at mean age 76 in a narrow-age sample of older individuals (n = 657 with brain volumetric data at the initial wave, n = 465 at follow-up). We used latent variable modeling to extract error-free cognitive levels and slopes. Initial levels of cognitive ability were predictive of subsequent brain tissue volume changes. Initial brain volumes were not predictive of subsequent cognitive changes. Brain volume changes, especially increases in WMH, were associated with declines in each of the cognitive abilities. All statistically significant results were modest in size (absolute r-values ranged from 0.114 to 0.334). These results build a comprehensive picture of macrostructural brain volume changes and declines in important cognitive faculties during the eighth decade of life.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Cognição / Envelhecimento Cognitivo Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Cognição / Envelhecimento Cognitivo Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article