Antenatal hypoxia induces epigenetic repression of glucocorticoid receptor and promotes ischemic-sensitive phenotype in the developing heart.

Xiong, Fuxia; Lin, Thant; Song, Minwoo; Ma, Qingyi; Martinez, Shannalee R; Lv, Juanxiu; MataGreenwood, Eugenia; Xiao, Daliao; Xu, Zhice; Zhang, Lubo

Xiong, Fuxia; Lin, Thant; Song, Minwoo; Ma, Qingyi; Martinez, Shannalee R; Lv, Juanxiu; MataGreenwood, Eugenia; Xiao, Daliao; Xu, Zhice; Zhang, Lubo.

Afiliação

Xiong F; Institute for Fetology and Reproductive Medicine Center, First Hospital of Soochow University, Suzhou, China; Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Lin T; Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Song M; Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Ma Q; Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Martinez SR; Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Lv J; Institute for Fetology and Reproductive Medicine Center, First Hospital of Soochow University, Suzhou, China; Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.
MataGreenwood E; Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Xiao D; Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Xu Z; Institute for Fetology and Reproductive Medicine Center, First Hospital of Soochow University, Suzhou, China; Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Zhang L; Institute for Fetology and Reproductive Medicine Center, First Hospital of Soochow University, Suzhou, China; Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA. Electronic address: lzhang@llu.edu.

J Mol Cell Cardiol ; 91: 160-71, 2016 Feb.

Article em En | MEDLINE | ID: mdl-26779948

Assuntos

Epigênese Genética; Hipóxia/genética; Traumatismo por Reperfusão Miocárdica/genética; Oxigênio/farmacologia; Receptores de Glucocorticoides/genética; Fator de Transcrição Sp1/genética; Animais; Animais Recém-Nascidos; Azacitidina/análogos & derivados; Azacitidina/farmacologia; Sítios de Ligação; Metilação de DNA/efeitos dos fármacos; Decitabina; Éxons; Feminino; Hipóxia/tratamento farmacológico; Hipóxia/metabolismo; Hipóxia/patologia; Masculino; Exposição Materna; Traumatismo por Reperfusão Miocárdica/metabolismo; Traumatismo por Reperfusão Miocárdica/patologia; Traumatismo por Reperfusão Miocárdica/prevenção & controle; Fenótipo; Gravidez; Regiões Promotoras Genéticas; Ligação Proteica; Ratos; Ratos Sprague-Dawley; Receptores de Glucocorticoides/antagonistas & inibidores; Receptores de Glucocorticoides/metabolismo; Elementos de Resposta; Fator de Transcrição Sp1/metabolismo

Palavras-chave

DNA methylation; Fetal programming; Glucocorticoid receptor; Hypoxia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxigênio / Traumatismo por Reperfusão Miocárdica / Receptores de Glucocorticoides / Fator de Transcrição Sp1 / Epigênese Genética / Hipóxia Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google