Reduced numbers of mucosal DR(int) macrophages and increased numbers of CD103(+) dendritic cells during anti-TNF-&#945; treatment in patients with Crohn's disease.

Dige, Anders; Magnusson, Maria K; Öhman, Lena; Hvas, Christian Lodberg; Kelsen, Jens; Wick, Mary Jo; Agnholt, Jørgen

Reduced numbers of mucosal DR(int) macrophages and increased numbers of CD103(+) dendritic cells during anti-TNF-α treatment in patients with Crohn's disease.

Dige, Anders; Magnusson, Maria K; Öhman, Lena; Hvas, Christian Lodberg; Kelsen, Jens; Wick, Mary Jo; Agnholt, Jørgen.

Afiliação

Dige A; a Gastro-Immuno Research Laboratory (GIRL), Department of Hepatology and Gastroenterology , Aarhus University Hospital , Aarhus , Denmark ;
Magnusson MK; b Department of Microbiology and Immunology , Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden ;
Öhman L; c Department of Internal Medicine and Clinical Nutrition , Institute for Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.
Hvas CL; b Department of Microbiology and Immunology , Institute for Biomedicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden ;
Kelsen J; c Department of Internal Medicine and Clinical Nutrition , Institute for Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.
Wick MJ; a Gastro-Immuno Research Laboratory (GIRL), Department of Hepatology and Gastroenterology , Aarhus University Hospital , Aarhus , Denmark ;
Agnholt J; a Gastro-Immuno Research Laboratory (GIRL), Department of Hepatology and Gastroenterology , Aarhus University Hospital , Aarhus , Denmark ;

Scand J Gastroenterol ; 51(6): 692-9, 2016.

Article em En | MEDLINE | ID: mdl-26784676

Assuntos

Adalimumab/farmacologia; Anti-Inflamatórios/farmacologia; Doença de Crohn/tratamento farmacológico; Células Dendríticas/efeitos dos fármacos; Mucosa Intestinal/efeitos dos fármacos; Macrófagos/efeitos dos fármacos; Adalimumab/uso terapêutico; Anti-Inflamatórios/uso terapêutico; Antígenos CD/metabolismo; Biomarcadores/metabolismo; Biópsia; Colo/efeitos dos fármacos; Colo/imunologia; Colo/patologia; Doença de Crohn/imunologia; Doença de Crohn/patologia; Células Dendríticas/imunologia; Células Dendríticas/patologia; Feminino; Citometria de Fluxo; Humanos; Íleo/efeitos dos fármacos; Íleo/imunologia; Íleo/patologia; Cadeias alfa de Integrinas/metabolismo; Mucosa Intestinal/patologia; Macrófagos/imunologia; Macrófagos/patologia; Masculino

Palavras-chave

Adalimumab; Crohn's disease; anti-TNF-α treatment; dendritic cell; macrophage

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Dendríticas / Doença de Crohn / Adalimumab / Mucosa Intestinal / Macrófagos / Anti-Inflamatórios Tipo de estudo: Observational_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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