The DNA damage-induced cell death response: a roadmap to kill cancer cells.
Cell Mol Life Sci
; 73(15): 2829-50, 2016 08.
Article
em En
| MEDLINE
| ID: mdl-26791483
ABSTRACT
Upon massive DNA damage cells fail to undergo productive DNA repair and trigger the cell death response. Resistance to cell death is linked to cellular transformation and carcinogenesis as well as radio- and chemoresistance, making the underlying signaling pathways a promising target for therapeutic intervention. Diverse DNA damage-induced cell death pathways are operative in mammalian cells and finally culminate in the induction of programmed cell death via activation of apoptosis or necroptosis. These signaling routes affect nuclear, mitochondria- and plasma membrane-associated key molecules to activate the apoptotic or necroptotic response. In this review, we highlight the main signaling pathways, molecular players and mechanisms guiding the DNA damage-induced cell death response.
Palavras-chave
ATM; ATR; Adriamycin; Axin; BAX; Cancer therapy; Caspase 2; Chk1; Chk2; Doxorubicin; FOXO3; HIPK2; Hippo pathway; Ionizing radiation; MLKL; PIDD; PML; PUMA; Pin1; RIPK1; RIPK3; SUMO; XAF1; Yap1; c-Abl; p53; p53 Serine 46; p73
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
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Transdução de Sinais
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Morte Celular
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Reparo do DNA
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Neoplasias
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article