Engineered bacterial polyester hydrolases efficiently degrade polyethylene terephthalate due to relieved product inhibition.

Wei, Ren; Oeser, Thorsten; Schmidt, Juliane; Meier, René; Barth, Markus; Then, Johannes; Zimmermann, Wolfgang

Wei, Ren; Oeser, Thorsten; Schmidt, Juliane; Meier, René; Barth, Markus; Then, Johannes; Zimmermann, Wolfgang.

Afiliação

Wei R; Department of Microbiology and Bioprocess Technology, Institute of Biochemistry, Leipzig University, Johannisallee 21-23, 04103 Leipzig, Germany.
Oeser T; Department of Microbiology and Bioprocess Technology, Institute of Biochemistry, Leipzig University, Johannisallee 21-23, 04103 Leipzig, Germany.
Schmidt J; Department of Microbiology and Bioprocess Technology, Institute of Biochemistry, Leipzig University, Johannisallee 21-23, 04103 Leipzig, Germany.
Meier R; Department of Biochemistry and Bioorganic Chemistry, Institute of Biochemistry, Leipzig University, Leipzig, Germany.
Barth M; Department of Microbiology and Bioprocess Technology, Institute of Biochemistry, Leipzig University, Johannisallee 21-23, 04103 Leipzig, Germany.
Then J; Department of Microbiology and Bioprocess Technology, Institute of Biochemistry, Leipzig University, Johannisallee 21-23, 04103 Leipzig, Germany.
Zimmermann W; Department of Microbiology and Bioprocess Technology, Institute of Biochemistry, Leipzig University, Johannisallee 21-23, 04103 Leipzig, Germany. wolfgang.zimmermann@uni-leipzig.de.

Biotechnol Bioeng ; 113(8): 1658-65, 2016 08.

Article em En | MEDLINE | ID: mdl-26804057

Assuntos

Proteínas de Bactérias/metabolismo; Hidrolases/metabolismo; Poliésteres/metabolismo; Polietilenotereftalatos/metabolismo; Proteínas Recombinantes/metabolismo; Actinobacteria/enzimologia; Actinobacteria/genética; Proteínas de Bactérias/química; Proteínas de Bactérias/genética; Biocatálise; Estabilidade Enzimática; Escherichia coli; Hidrolases/química; Hidrolases/genética; Hidrólise; Mutagênese Sítio-Dirigida; Poliésteres/análise; Poliésteres/química; Polietilenotereftalatos/análise; Polietilenotereftalatos/química; Proteínas Recombinantes/química; Proteínas Recombinantes/genética

Palavras-chave

biocatalysis; hydrolase; polyester; polyethylene terephthalate; product inhibition

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poliésteres / Proteínas de Bactérias / Proteínas Recombinantes / Polietilenotereftalatos / Hidrolases Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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