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Discovery of diamide compounds as diacylglycerol acyltransferase 1 (DGAT1) inhibitors.
Nakajima, Katsumasa; April, Myriam; Brewer, Jason T; Daniels, Thomas; Forster, Cornelia J; Gilmore, Thomas A; Jain, Monish; Kanter, Aaron; Kwak, Youngshin; Li, Jingzhou; McQuire, Les; Serrano-Wu, Michael H; Streeper, Ryan; Szklennik, Paul; Thompson, James; Wang, Bing.
Afiliação
  • Nakajima K; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA.
  • April M; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA.
  • Brewer JT; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA.
  • Daniels T; Cardiovascular and Metabolism, Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA.
  • Forster CJ; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA.
  • Gilmore TA; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA.
  • Jain M; Metabolism and Pharmacokinetics, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA.
  • Kanter A; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA.
  • Kwak Y; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA.
  • Li J; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA.
  • McQuire L; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA.
  • Serrano-Wu MH; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA.
  • Streeper R; Cardiovascular and Metabolism, Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA.
  • Szklennik P; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA.
  • Thompson J; Cardiovascular and Metabolism, Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA.
  • Wang B; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA.
Bioorg Med Chem Lett ; 26(4): 1245-8, 2016 Feb 15.
Article em En | MEDLINE | ID: mdl-26804232
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diamida / Inibidores Enzimáticos / Diacilglicerol O-Aciltransferase Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diamida / Inibidores Enzimáticos / Diacilglicerol O-Aciltransferase Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article