Maternal and Neonatal Levels of Perfluoroalkyl Substances in Relation to Gestational Weight Gain.
Int J Environ Res Public Health
; 13(1)2016 Jan 20.
Article
em En
| MEDLINE
| ID: mdl-26805861
ABSTRACT
Perfluoroalkyl substances (PFASs) are ubiquitous, persistent pollutants widely used in the production of common household and consumer goods. There is a limited body of literature suggesting that these chemicals may alter metabolic pathways and growth trajectories. The relationship between prenatal exposures to these chemicals and gestational weight gain (GWG) has received limited attention. One objective was to analyze the associations among maternal plasma levels of three common perfluoroalkyl substances (perfluorooctanoate (PFOA), perfluorooctanesulfonate (PFOS), perfluorohexanesulfanoate (PFHxS)) and GWG. Additionally, we explored whether GWG was associated with cord blood PFAS levels. This study utilized data collected in the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a trans-Canada cohort study of 2001 pregnant women. Our analysis quantified associations between (1) maternal PFAS concentrations and GWG and (2) GWG and cord blood PFAS concentrations. Maternal PFOS concentrations were positively associated with GWG (ß = 0.39 95% CI 0.02, 0.75). Interquartile increases in GWG were significantly associated with elevated cord blood PFOA (OR = 1.33; 95% CI 1.13 to 1.56) and PFOS (OR = 1.20; 95% CI 1.03 to 1.40) concentrations. No statistically significant associations were observed between GWG and either measure of PFHxS. These findings warrant elucidation of the potential underlying mechanisms.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido
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Substâncias Perigosas
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Exposição Materna
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Poluentes Ambientais
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Sangue Fetal
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Fluorocarbonos
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Troca Materno-Fetal
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
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Pregnancy
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article