Upregulation of AMWAP: a novel mechanism for HDAC inhibitors to protect against cisplatin nephrotoxicity.
Kidney Int
; 89(2): 267-9, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26806827
ABSTRACT
Histone deacetylases have been reported to protect against renal tubular damage in several animal models of acute renal injury, including cisplatin nephrotoxicity. However, the mechanism involved is not well defined. In this study, Ranganathan et al. identify activated microglia/macrophage WAP domain protein as the novel mediator of histone deacetylase inhibitor-mediated renal protection in a murine model of cisplatin nephrotoxicity. Activated microglia/macrophage WAP-mediated renal protection is associated with suppression of inflammation and renal epithelial cell apoptosis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cisplatino
/
Inibidores de Histona Desacetilases
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article