Crocin protects against doxorubicin-induced myocardial toxicity in rats through down-regulation of inflammatory and apoptic pathways.

Elsherbiny, Nehal M; Salama, Mohamed F; Said, Eman; El-Sherbiny, Mohamed; Al-Gayyar, Mohammed M H

Elsherbiny, Nehal M; Salama, Mohamed F; Said, Eman; El-Sherbiny, Mohamed; Al-Gayyar, Mohammed M H.

Afiliação

Elsherbiny NM; Department of Clinical Biochemistry, Faculty of Pharmacy, University of Mansoura, 35516, Egypt.
Salama MF; Program in Pharmaceutical Sciences, Faculty of Pharmacy, University of Mansoura, Mansoura, 35516, Egypt.
Said E; Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Mansoura, 35516, Egypt. Electronic address: emansaid@mans.edu.eg.
El-Sherbiny M; Department of Anatomy, Faculty of Medicine, University of Mansoura, 35516, Egypt.
Al-Gayyar MM; Department of Clinical Biochemistry, Faculty of Pharmacy, University of Mansoura, 35516, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk, 71491, Saudi Arabia.

Chem Biol Interact ; 247: 39-48, 2016 Mar 05.

Article em En | MEDLINE | ID: mdl-26807765

Assuntos

Apoptose/efeitos dos fármacos; Carotenoides/farmacologia; Regulação para Baixo/efeitos dos fármacos; Doxorrubicina/toxicidade; Coração/efeitos dos fármacos; Inflamação/prevenção & controle; Animais; Cálcio/metabolismo; Eletrocardiografia; Masculino; Ratos; Ratos Sprague-Dawley; Troponina T/antagonistas & inibidores

Palavras-chave

Caspase-3; Crocin; Doxorubicin; Electrocardiogram; Interleukins; Tumor necrosis factor (TNF)-α

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carotenoides / Doxorrubicina / Regulação para Baixo / Apoptose / Coração / Inflamação Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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