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An adaptive immune response driven by mature, antigen-experienced T and B cells within the microenvironment of oral squamous cell carcinoma.
Quan, Hongzhi; Fang, Liangjuan; Pan, Hao; Deng, Zhiyuan; Gao, Shan; Liu, Ousheng; Wang, Yuehong; Hu, Yanjia; Fang, Xiaodan; Yao, Zhigang; Guo, Feng; Lu, Ruohuang; Xia, Kun; Tang, Zhangui.
Afiliação
  • Quan H; State Key Laboratory of Medical Genetics, School of Life Science, Central South University, Changsha, Hunan, 410013, People's Republic of China.
  • Fang L; Research Institution of Stomatology, Xiangya Stomatological Hospital & School of Stomatology, Central South University, Changsha, Hunan, 410078, People's Republic of China.
  • Pan H; Department of Oral Maxillofacial Surgery, Xiangya Stomatological Hospital & School of Stomatology, Central South University, Changsha, Hunan, 410078, People's Republic of China.
  • Deng Z; Department of Immunobiology, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, People's Republic of China.
  • Gao S; Research Institution of Stomatology, Xiangya Stomatological Hospital & School of Stomatology, Central South University, Changsha, Hunan, 410078, People's Republic of China.
  • Liu O; Research Institution of Stomatology, Xiangya Stomatological Hospital & School of Stomatology, Central South University, Changsha, Hunan, 410078, People's Republic of China.
  • Wang Y; Research Institution of Stomatology, Xiangya Stomatological Hospital & School of Stomatology, Central South University, Changsha, Hunan, 410078, People's Republic of China.
  • Hu Y; Department of Molecular Biology, University of Aarhus, Aarhus C, DK-8000, Denmark.
  • Fang X; Research Institution of Stomatology, Xiangya Stomatological Hospital & School of Stomatology, Central South University, Changsha, Hunan, 410078, People's Republic of China.
  • Yao Z; Research Institution of Stomatology, Xiangya Stomatological Hospital & School of Stomatology, Central South University, Changsha, Hunan, 410078, People's Republic of China.
  • Guo F; Department of Oral Maxillofacial Surgery, Xiangya Stomatological Hospital & School of Stomatology, Central South University, Changsha, Hunan, 410078, People's Republic of China.
  • Lu R; Research Institution of Stomatology, Xiangya Stomatological Hospital & School of Stomatology, Central South University, Changsha, Hunan, 410078, People's Republic of China.
  • Xia K; Department of Oral Maxillofacial Surgery, Xiangya Stomatological Hospital & School of Stomatology, Central South University, Changsha, Hunan, 410078, People's Republic of China.
  • Tang Z; State Key Laboratory of Medical Genetics, School of Life Science, Central South University, Changsha, Hunan, 410013, People's Republic of China.
Int J Cancer ; 138(12): 2952-62, 2016 Jun 15.
Article em En | MEDLINE | ID: mdl-26815146
ABSTRACT
Lymphocyte infiltrates have been observed in the microenvironment of oral cancer; however, little is known about whether the immune response of the lymphocyte infiltrate affects tumor biology. For a deeper understanding of the role of the infiltrating-lymphocytes in oral squamous cell carcinoma (OSCC), we characterized the lymphocyte infiltrate repertoires and defined their features. Immunohistochemistry revealed considerable T and B cell infiltrates and lymphoid follicles with germinal center-like structures within the tumor microenvironment. Flow cytometry demonstrated that populations of antigen-experienced CD4+ and CD8+ cells were present, as well as an enrichment of regulatory T cells; and T cells expressing programmed death-1 (PD-1) and T cell Ig and mucin protein-3 (Tim-3), indicative of exhaustion, within the tumor microenvironment. Characterization of tumor-infiltrating B cells revealed clear evidence of antigen exposure, in that the cardinal features of an antigen-driven B cell response were present, including somatic mutation, clonal expansion, intraclonal variation and isotype switching. Collectively, our results point to an adaptive immune response occurring within the OSCC microenvironment, which may be sustained by the expression of specific antigens in the tumor.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Linfócitos B / Carcinoma de Células Escamosas / Linfócitos T Reguladores / Imunidade Adaptativa / Microambiente Tumoral Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Linfócitos B / Carcinoma de Células Escamosas / Linfócitos T Reguladores / Imunidade Adaptativa / Microambiente Tumoral Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article