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Systems-Wide Prediction of Enzyme Promiscuity Reveals a New Underground Alternative Route for Pyridoxal 5'-Phosphate Production in E. coli.
Oberhardt, Matthew A; Zarecki, Raphy; Reshef, Leah; Xia, Fangfang; Duran-Frigola, Miquel; Schreiber, Rachel; Henry, Christopher S; Ben-Tal, Nir; Dwyer, Daniel J; Gophna, Uri; Ruppin, Eytan.
Afiliação
  • Oberhardt MA; School of Computer Sciences and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Zarecki R; Department of Molecular Microbiology and Biotechnology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
  • Reshef L; Center for Bioinformatics and Computational Biology, Department of Computer Science, University of Maryland, College Park, Maryland, United States of America.
  • Xia F; School of Computer Sciences and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Duran-Frigola M; Department of Molecular Microbiology and Biotechnology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
  • Schreiber R; Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, Illinois, United States of America.
  • Henry CS; Joint IRB-BSC-CRG Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain.
  • Ben-Tal N; Department of Molecular Microbiology and Biotechnology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
  • Dwyer DJ; Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, Illinois, United States of America.
  • Gophna U; Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
  • Ruppin E; Department of Cell Biology and Molecular Genetics, Institute for Physical Science and Technology, Department of Bioengineering, Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, United States of America.
PLoS Comput Biol ; 12(1): e1004705, 2016 Jan.
Article em En | MEDLINE | ID: mdl-26821166
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfato de Piridoxal / Biologia Computacional / Escherichia coli Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfato de Piridoxal / Biologia Computacional / Escherichia coli Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article