Mechanisms and Dynamics of Protein Acetylation in Mitochondria.
Trends Biochem Sci
; 41(3): 231-244, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26822488
ABSTRACT
Reversible protein acetylation is a major regulatory mechanism for controlling protein function. Through genetic manipulations, dietary perturbations, and new proteomic technologies, the diverse functions of protein acetylation are coming into focus. Protein acetylation in mitochondria has taken center stage, revealing that 63% of mitochondrially localized proteins contain lysine acetylation sites. We summarize the field and discuss salient topics that cover spurious versus targeted acetylation, the role of SIRT3 deacetylation, nonenzymatic acetylation, and molecular models for regulatory acetylations that display high and low stoichiometry.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Mitocôndrias
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article