Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine.
Science
; 351(6275): 858-63, 2016 Feb 19.
Article
em En
| MEDLINE
| ID: mdl-26822607
Dietary antigens are normally rendered nonimmunogenic through a poorly understood "oral tolerance" mechanism that involves immunosuppressive regulatory T (Treg) cells, especially Treg cells induced from conventional T cells in the periphery (pTreg cells). Although orally introducing nominal protein antigens is known to induce such pTreg cells, whether a typical diet induces a population of pTreg cells under normal conditions thus far has been unknown. By using germ-free mice raised and bred on an elemental diet devoid of dietary antigens, we demonstrated that under normal conditions, the vast majority of the small intestinal pTreg cells are induced by dietary antigens from solid foods. Moreover, these pTreg cells have a limited life span, are distinguishable from microbiota-induced pTreg cells, and repress underlying strong immunity to ingested protein antigens.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Alimentares
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Linfócitos T Reguladores
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Dispepsia
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Microbioma Gastrointestinal
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Intestino Delgado
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article