Relationship between CIP2A expression, and prognosis and MDR-related proteins in patients with advanced gastric cancer.
Int J Clin Exp Pathol
; 8(11): 15007-12, 2015.
Article
em En
| MEDLINE
| ID: mdl-26823836
ABSTRACT
CIP2A is highly expressed in a variety of malignancies. We determined the expression and clinical significance of CIP2A in patients with advanced gastric cancer. CIP2A protein was expressed in 25 of 37 cancer tissue specimens. There was no correlation between CIP2A and PGP, GST-π, Topo-II, and LRP expression. Survival analysis showed significant differences between the survival rate of the CIP2A protein-positive and -negative groups (χ(2)=4.509, P=0.034), but the degree of positive expression was unrelated to survival time (χ(2)=4.639, P=0.098). CIP2A expression may have no prospective value for optimizing chemotherapy regimens, but it can be an indicator for patient prognosis.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autoantígenos
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Neoplasias Gástricas
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Adenocarcinoma
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Biomarcadores Tumorais
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Subfamília B de Transportador de Cassetes de Ligação de ATP
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Proteínas de Membrana
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article