Linking mobile source-PAHs and biological effects in traffic police officers and drivers in Rawalpindi (Pakistan).
Ecotoxicol Environ Saf
; 127: 135-43, 2016 May.
Article
em En
| MEDLINE
| ID: mdl-26827277
ABSTRACT
The aim of this study was to evaluate the effect of traffic related polycyclic aromatic hydrocarbons (PAHs) on blood parameters of subjects, including traffic police officers (TP), drivers (DR) and control subjects (CN) with presumably different levels of exposure. We quantified the urinary 1-hydroxypyrene (1-OHPyr), α-naphthol and ß-naphthol (α- and ß-naph) as biomarkers of exposure to PAHs in relation with biomarkers of effect (Hb, MCV, PCV, PLT, RBCs), biomarkers of inflammation/infection (CRP, WBCs), oxidative stress (SOD) and oxidative DNA damage i.e. 8-hydroxy-2-deoxyguanosine (8-OHdG). Results showed that mean 1-OHPyr, α-naph and ß-naph concentrations were significantly higher in TPs (0.98, 1.55, and 1.9µmolmol-Cr(-1), respectively, p<0.05) than CNs (0.7, 0.6; 0.67µmolmol-Cr(-1), respectively, P<0.05). Furthermore, WBC and CRP were found in higher concentrations in TPs than CNs (7.04×10(3)µL(-1) and 0.95mgL(-1) vs. 5.1×10(3)µL(-1) and 0.54mgL(-1), respectively). The urinary 8-OHdG level, a biomarker of oxidative DNA damage, was higher in TPs than both CN and DR subjects (48ngmg-Cr(-1), 24ngmg-Cr(-1) and 33ngmg-Cr(-1), respectively). Self-reported health assessment indicates that, on the basis of daily time spent in the middle of heavy traffic, TPs and DRs more frequently suffered from adverse head and respiratory symptoms. The PCA analysis evidenced the impact of traffic pollution on exposure biomarkers and DNA damage. The study suggests that traffic pollution may be associated with important health risk, in particular on the respiratory system, not only for workers exposed to traffic exhausts but also for general public. Finally, vehicular air pollution in the city of Rawalpindi should be a high-priority concern for the Pakistan Government that needs to be addressed.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Condução de Veículo
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Emissões de Veículos
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Exposição Ocupacional
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Polícia
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Poluição do Ar
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Adult
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Humans
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Male
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Middle aged
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article