Co-expression of the protease furin in Nicotiana benthamiana leads to efficient processing of latent transforming growth factor-ß1 into a biologically active protein.

Wilbers, Ruud H P; Westerhof, Lotte B; van Raaij, Debbie R; van Adrichem, Marloes; Prakasa, Andreas D; Lozano-Torres, Jose L; Bakker, Jaap; Smant, Geert; Schots, Arjen

Wilbers, Ruud H P; Westerhof, Lotte B; van Raaij, Debbie R; van Adrichem, Marloes; Prakasa, Andreas D; Lozano-Torres, Jose L; Bakker, Jaap; Smant, Geert; Schots, Arjen.

Afiliação

Wilbers RH; Laboratory of Nematology, Plant Sciences Department, Wageningen University and Research Centre, Wageningen, The Netherlands.
Westerhof LB; Laboratory of Nematology, Plant Sciences Department, Wageningen University and Research Centre, Wageningen, The Netherlands.
van Raaij DR; Laboratory of Nematology, Plant Sciences Department, Wageningen University and Research Centre, Wageningen, The Netherlands.
van Adrichem M; Laboratory of Nematology, Plant Sciences Department, Wageningen University and Research Centre, Wageningen, The Netherlands.
Prakasa AD; Laboratory of Nematology, Plant Sciences Department, Wageningen University and Research Centre, Wageningen, The Netherlands.
Lozano-Torres JL; Laboratory of Nematology, Plant Sciences Department, Wageningen University and Research Centre, Wageningen, The Netherlands.
Bakker J; Laboratory of Nematology, Plant Sciences Department, Wageningen University and Research Centre, Wageningen, The Netherlands.
Smant G; Laboratory of Nematology, Plant Sciences Department, Wageningen University and Research Centre, Wageningen, The Netherlands.
Schots A; Laboratory of Nematology, Plant Sciences Department, Wageningen University and Research Centre, Wageningen, The Netherlands.

Plant Biotechnol J ; 14(8): 1695-704, 2016 08.

Article em En | MEDLINE | ID: mdl-26834022

Assuntos

Furina/metabolismo; Nicotiana/genética; Proteínas Recombinantes de Fusão/metabolismo; Fator de Crescimento Transformador beta1/metabolismo; Fator de Crescimento Transformador beta1/farmacologia; Animais; Linhagem Celular; Células Epiteliais/efeitos dos fármacos; Furina/genética; Humanos; Cadeias alfa de Imunoglobulina/genética; Cadeias alfa de Imunoglobulina/metabolismo; Vison; Folhas de Planta/genética; Folhas de Planta/metabolismo; Plantas Geneticamente Modificadas; Redobramento de Proteína; Sinais Direcionadores de Proteínas/genética; Proteínas Recombinantes de Fusão/genética; Proteínas Recombinantes de Fusão/farmacologia; Nicotiana/metabolismo; Fator de Crescimento Transformador beta1/genética

Palavras-chave

Nicotiana benthamiana; codon optimization; furin; proteolytic processing; signal peptide; transforming growth factor ß1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nicotiana / Proteínas Recombinantes de Fusão / Furina / Fator de Crescimento Transformador beta1 Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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