Blockade of dorsolateral pontine 5HT1A receptors destabilizes the respiratory rhythm in C57BL6/J wild-type mice.
Respir Physiol Neurobiol
; 226: 110-4, 2016 06.
Article
em En
| MEDLINE
| ID: mdl-26840837
ABSTRACT
The neurotransmitter serotonin (5HT) acting via 5HT1a receptors (5HT1aR) is a potent determinant of respiratory rhythm variability. Here, we address the 5HT1aR-dependent control of respiratory rhythm variability in C57BL6/J mice. Using the in situ perfused preparation, we compared the effects of systemic versus focal blockade of 5HT1aRs. Blocking 5HT1aRs in the Kölliker-Fuse nucleus (KFn) increased the occurrence of spontaneous apneas and accounted for the systemic effects of 5HT1aR antagonists. Further, 5HT1aRs of the KFn stabilized the respiratory rhythm's response to arterial chemoreflex perturbations; reducing the recovering time, e.g., the latency to return to the baseline pattern. Together, these results suggest that the KFn regulates both intrinsic and sensory determinants of respiratory rhythm variability.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Piperazinas
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Respiração
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Cicloexanos
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Receptor 5-HT1A de Serotonina
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Antagonistas do Receptor 5-HT1 de Serotonina
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Núcleo de Kölliker-Fuse
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article