[Inhibition of NF-kB Activation Decreases Resistance in Acute Myeloid Leukemia Cells to TRAIL-induced Apoptosis in Multicellular Aggregates].
Biofizika
; 60(6): 1146-50, 2015.
Article
em Ru
| MEDLINE
| ID: mdl-26841509
ABSTRACT
Suppression of resistance in acute myeloid leukemia cells to TRAIL-induced apoptosis in multicellular aggregates, was studied using small molecule inhibitors of the activation of the transcription factor NF-kB - NF-k9 Activation Inhibitor IV and JSH-23 at non-toxic concentrations. NF-kB Activation Inhibitor IV and JSH-23 reduced resistance in the acute myeloid leukemia cells in multicellular aggregates to cytotoxic action of recombinant protein izTRAIL. It is shown that the use of these inhibitors decreased the phosphorylation of the RelA (p65) as a main marker activation of the transcription factor NF-kB. We discuss a possible reason for increasing resistance in acute myeloid leukemia cells to TRAIL-induced apoptosis in multicellular aggregates.
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Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide Aguda
/
NF-kappa B
/
Fator de Transcrição RelA
/
Ligante Indutor de Apoptose Relacionado a TNF
Limite:
Humans
Idioma:
Ru
Ano de publicação:
2015
Tipo de documento:
Article