A TET2 rs3733609 C/T genotype is associated with predisposition to the myeloproliferative neoplasms harboring JAK2(V617F) and confers a proliferative potential on erythroid lineages.

Shen, Xiao-hui; Sun, Nan-nan; Yin, Ya-fei; Liu, Su-fang; Liu, Xiao-liu; Peng, Hong-ling; Dai, Chong-wen; Xu, Yun-xiao; Deng, Ming-yang; Luo, Yun-ya; Zheng, Wen-li; Zhang, Guang-sen

Shen, Xiao-hui; Sun, Nan-nan; Yin, Ya-fei; Liu, Su-fang; Liu, Xiao-liu; Peng, Hong-ling; Dai, Chong-wen; Xu, Yun-xiao; Deng, Ming-yang; Luo, Yun-ya; Zheng, Wen-li; Zhang, Guang-sen.

Afiliação

Shen XH; Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Sun NN; Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Yin YF; Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Liu SF; Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Liu XL; Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Peng HL; Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Dai CW; Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Xu YX; Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Deng MY; Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Luo YY; Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Zheng WL; Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Zhang GS; Division of Hematology, Institute of Molecular Hematology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.

Oncotarget ; 7(8): 9550-60, 2016 Feb 23.

Article em En | MEDLINE | ID: mdl-26843622

Assuntos

Proteínas de Ligação a DNA/genética; Predisposição Genética para Doença; Janus Quinase 2/genética; Policitemia Vera/genética; Polimorfismo de Nucleotídeo Único/genética; Mielofibrose Primária/genética; Proteínas Proto-Oncogênicas/genética; Trombocitemia Essencial/genética; Adulto; Idoso; Idoso de 80 Anos ou mais; Povo Asiático/genética; Proteínas Estimuladoras de Ligação a CCAAT/metabolismo; Dioxigenases; Frequência do Gene/genética; Genótipo; Humanos; Pessoa de Meia-Idade; Adulto Jovem

Palavras-chave

TET2; clinical significance; mechanisms; myeloproliferative neoplasms; rs3733609

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Policitemia Vera / Proteínas Proto-Oncogênicas / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Proteínas de Ligação a DNA / Janus Quinase 2 / Mielofibrose Primária / Trombocitemia Essencial Tipo de estudo: Risk_factors_studies Limite: Adult / Aged / Aged80 / Humans / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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