Helicobacter pylori CagA induces tumor suppressor gene hypermethylation by upregulating DNMT1 via AKT-NF&#954;B pathway in gastric cancer development.

Zhang, Bao-gui; Hu, Lei; Zang, Ming-de; Wang, He-xiao; Zhao, Wei; Li, Jian-fang; Su, Li-ping; Shao, Zhifeng; Zhao, Xiaodong; Zhu, Zheng-gang; Yan, Min; Liu, Bingya

Helicobacter pylori CagA induces tumor suppressor gene hypermethylation by upregulating DNMT1 via AKT-NFκB pathway in gastric cancer development.

Zhang, Bao-gui; Hu, Lei; Zang, Ming-de; Wang, He-xiao; Zhao, Wei; Li, Jian-fang; Su, Li-ping; Shao, Zhifeng; Zhao, Xiaodong; Zhu, Zheng-gang; Yan, Min; Liu, Bingya.

Afiliação

Zhang BG; Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Hu L; Affiliated Hospital of Jining Medical University, Jining, People's Republic of China.
Zang MD; Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Wang HX; Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Zhao W; Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Li JF; Department of Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Su LP; Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Shao Z; Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Zhao X; Bio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Zhu ZG; Bio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Yan M; Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Liu B; Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Oncotarget ; 7(9): 9788-800, 2016 Mar 01.

Article em En | MEDLINE | ID: mdl-26848521

Assuntos

Antígenos de Bactérias/metabolismo; Proteínas de Bactérias/metabolismo; DNA (Citosina-5-)-Metiltransferases/biossíntese; Metilação de DNA/genética; Helicobacter pylori/metabolismo; NF-kappa B/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Neoplasias Gástricas/genética; Animais; Antígenos de Bactérias/genética; Proteínas de Bactérias/genética; Linhagem Celular Tumoral; Ilhas de CpG/genética; DNA (Citosina-5-)-Metiltransferase 1; DNA (Citosina-5-)-Metiltransferases/genética; Metilases de Modificação do DNA/genética; Metilases de Modificação do DNA/metabolismo; Enzimas Reparadoras do DNA/genética; Enzimas Reparadoras do DNA/metabolismo; Ativação Enzimática; Genes Supressores de Tumor; Infecções por Helicobacter/microbiologia; Humanos; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos C57BL; Fosforilação; Regiões Promotoras Genéticas/genética; Proteínas Serina-Treonina Quinases/metabolismo; Piruvato Desidrogenase Quinase de Transferência de Acetil; Interferência de RNA; RNA Interferente Pequeno/genética; Proteínas Supressoras de Tumor/genética; Proteínas Supressoras de Tumor/metabolismo

Palavras-chave

AKT-NF-kB pathway; DNMT1; H. pylori CagA; gastric cancer development; hypermethylation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Proteínas de Bactérias / NF-kappa B / Helicobacter pylori / Metilação de DNA / DNA (Citosina-5-)-Metiltransferases / Proteínas Proto-Oncogênicas c-akt / Antígenos de Bactérias Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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