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Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development.
Nair, Anilkumar G; Zeng, Qingbei; Selyutin, Oleg; Rosenblum, Stuart B; Jiang, Yueheng; Yang, De-Yi; Keertikar, Kerry; Zhou, Guowei; Dwyer, Michael P; Kim, Seong Heon; Shankar, Bandarpalle; Yu, Wensheng; Tong, Ling; Chen, Lei; Mazzola, Robert; Caldwell, John; Tang, Haiqun; Allard, Melissa L; Buckle, Ronald N; Gauuan, Polivina Jolicia F; Holst, Christian L; Martin, Gregory S; Naicker, Kannan P; Vellekoop, Samuel; Agrawal, Sony; Liu, Rong; Kong, Rong; Ingravallo, Paul; Xia, Ellen; Zhai, Ying; Nomeir, Amin; Kozlowski, Joseph A.
Afiliação
  • Nair AG; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Zeng Q; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Selyutin O; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Rosenblum SB; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Jiang Y; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Yang DY; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Keertikar K; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Zhou G; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Dwyer MP; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Kim SH; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Shankar B; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Yu W; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Tong L; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Chen L; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Mazzola R; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Caldwell J; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Tang H; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Allard ML; Albany Molecular Research Inc., 26 Corporate Circle, Albany, NY 12203, USA.
  • Buckle RN; Albany Molecular Research Inc., 26 Corporate Circle, Albany, NY 12203, USA.
  • Gauuan PJ; Albany Molecular Research Inc., 26 Corporate Circle, Albany, NY 12203, USA.
  • Holst CL; Albany Molecular Research Inc., 26 Corporate Circle, Albany, NY 12203, USA.
  • Martin GS; Albany Molecular Research Inc., 26 Corporate Circle, Albany, NY 12203, USA.
  • Naicker KP; Albany Molecular Research Inc., 26 Corporate Circle, Albany, NY 12203, USA.
  • Vellekoop S; Albany Molecular Research Inc., 26 Corporate Circle, Albany, NY 12203, USA.
  • Agrawal S; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Liu R; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Kong R; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Ingravallo P; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Xia E; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Zhai Y; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Nomeir A; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Kozlowski JA; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
Bioorg Med Chem Lett ; 26(5): 1475-9, 2016 Mar 01.
Article em En | MEDLINE | ID: mdl-26850003
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Silanos / Prolina / Proteínas não Estruturais Virais / Hepacivirus / Descoberta de Drogas Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Silanos / Prolina / Proteínas não Estruturais Virais / Hepacivirus / Descoberta de Drogas Idioma: En Ano de publicação: 2016 Tipo de documento: Article