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Cationic gadolinium chelate for magnetic resonance imaging of cartilaginous defects.
Nwe, Kido; Huang, Ching-Hui; Qu, Feini; Warden-Rothman, Robert; Zhang, Clare Y; Mauck, Robert L; Tsourkas, Andrew.
Afiliação
  • Nwe K; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
  • Huang CH; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
  • Qu F; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
  • Warden-Rothman R; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Zhang CY; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
  • Mauck RL; Department of Radiology, Coatesville Veterans Affairs Medical Center, Coatesville, PA, USA.
  • Tsourkas A; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Contrast Media Mol Imaging ; 11(3): 229-35, 2016 05.
Article em En | MEDLINE | ID: mdl-26853708
The ability to detect meniscus defects by magnetic resonance arthrography (MRA) can be highly variable. To improve the delineation of fine tears, we synthesized a cationic gadolinium complex, (Gd-DOTA-AM4 )(2+) , that can electrostatically interact with Glycosaminoglycans (GAGs). The complex has a longitudinal relaxivity (r1) of 4.2 mM(-1) s(-1) and is highly stable in serum. Its efficacy in highlighting soft tissue tears was evaluated in comparison to a clinically employed contrast agent (Magnevist) using explants obtained from adult bovine menisci. In all cases, Gd-DOTA-AM4 appeared to improve the ability to detect the soft tissue defect by providing increased signal intensity along the length of the tear. Magnevist shows a strong signal near the liquid-meniscus interface, but much less contrast is observed within the defect at greater depths. This provides initial evidence that cationic contrast agents can be used to improve the diagnostic accuracy of MRA. Copyright © 2016 John Wiley & Sons, Ltd.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ferimentos e Lesões / Imageamento por Ressonância Magnética / Cartilagem / Quelantes / Gadolínio Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ferimentos e Lesões / Imageamento por Ressonância Magnética / Cartilagem / Quelantes / Gadolínio Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article