Infrared-active quadruple contrast FePt nanoparticles for multiple scale molecular imaging.
Biomaterials
; 85: 54-64, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-26854391
ABSTRACT
A single nanomaterial with multiple imaging contrasts and functions is highly desired for multiscale theragnosis. Herein, we demonstrate single 1-1.9 µm infrared-active FePt alloy nanoparticles (FePt NPs) offering unprecedented four-contrast-in-one molecular imaging - computed tomography (CT), magnetic resonance imaging (MRI), photoacoustic (PA) imaging, and high-order multiphoton luminescence (HOMPL) microscopy. The PA response of FePt NPs outperforms that of infrared-active gold nanorods by 3- to 5.6-fold under identical excitation fluence and particle concentrations. HOMPL (680 nm) of an isolated FePt NP renders spatial full-width-at-half-maximum values of 432 nm and 300 nm beyond the optical diffraction limit for 1230-nm and 920-nm excitation, respectively. The in vivo targeting function was successfully visualized using HOMPL, PA imaging, CT, and MRI, thereby validating FePt as a single nanomaterial system covering up to four types (Optical/PA/CT/MRI) of molecular imaging contrast, ranging from the microscopic level to whole-body scale investigation.
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Base de dados:
MEDLINE
Assunto principal:
Platina
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Meios de Contraste
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Nanopartículas Metálicas
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Imagem Molecular
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Ferro
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article