Curcumin Ameliorates Reserpine-Induced Gastrointestinal Mucosal Lesions Through Inhibiting I&#954;B-&#945;/NF-&#954;B Pathway and Regulating Expression of Vasoactive Intestinal Peptide and Gastrin in Rats.

Long, Lingli; Wang, Jingnan; Chen, Ningning; Zheng, Shuhui; Shi, Lanying; Xu, Yuxia; Luo, Canqiao; Deng, Yubin

Curcumin Ameliorates Reserpine-Induced Gastrointestinal Mucosal Lesions Through Inhibiting IκB-α/NF-κB Pathway and Regulating Expression of Vasoactive Intestinal Peptide and Gastrin in Rats.

Long, Lingli; Wang, Jingnan; Chen, Ningning; Zheng, Shuhui; Shi, Lanying; Xu, Yuxia; Luo, Canqiao; Deng, Yubin.

Afiliação

Long L; 1 Research Center of Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University , Guangzhou, China .
Wang J; 1 Research Center of Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University , Guangzhou, China .
Chen N; 2 Department of Spine Surgery, Sun Yat-Sen University , Guangzhou, China .
Zheng S; 1 Research Center of Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University , Guangzhou, China .
Shi L; 3 Department of Traditional Chinese Medicine, Sun Yat-Sen University , Guangzhou, China .
Xu Y; 1 Research Center of Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University , Guangzhou, China .
Luo C; 4 Pathology, The First Affiliated Hospital, Sun Yat-Sen University , Guangzhou, China .
Deng Y; 1 Research Center of Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University , Guangzhou, China .

J Med Food ; 19(6): 528-34, 2016 Jun.

Article em En | MEDLINE | ID: mdl-26872103

Assuntos

Anti-Hipertensivos/efeitos adversos; Curcumina/administração & dosagem; Mucosa Gástrica/efeitos dos fármacos; Gastrinas/genética; Gastroenteropatias/tratamento farmacológico; Proteínas I-kappa B/metabolismo; NF-kappa B/metabolismo; Reserpina/efeitos adversos; Peptídeo Intestinal Vasoativo/genética; Animais; Mucosa Gástrica/lesões; Mucosa Gástrica/metabolismo; Gastrinas/metabolismo; Gastroenteropatias/etiologia; Gastroenteropatias/genética; Gastroenteropatias/metabolismo; Humanos; Proteínas I-kappa B/genética; Masculino; NF-kappa B/genética; Ratos; Ratos Sprague-Dawley; Transdução de Sinais/efeitos dos fármacos; Peptídeo Intestinal Vasoativo/metabolismo

Palavras-chave

NF-κB; apoptosis; curcumin; in vivo; inflammation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Reserpina / Gastrinas / Peptídeo Intestinal Vasoativo / NF-kappa B / Proteínas I-kappa B / Curcumina / Mucosa Gástrica / Gastroenteropatias / Anti-Hipertensivos Tipo de estudo: Etiology_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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