HIV-1 Reservoirs During Suppressive Therapy.
Trends Microbiol
; 24(5): 345-355, 2016 May.
Article
em En
| MEDLINE
| ID: mdl-26875617
ABSTRACT
The introduction of antiretroviral therapy (ART) 20 years ago has dramatically reduced morbidity and mortality associated with HIV-1. Initially there was hope that ART would be curative, but it quickly became clear that even though ART was able to restore CD4(+) T cell counts and suppress viral loads below levels of detection, discontinuation of treatment resulted in a rapid rebound of infection. This is due to persistence of a small reservoir of latently infected cells with a long half-life, which necessitates life-long ART. Over the past few years, significant progress has been made in defining and characterizing the latent reservoir of HIV-1, and here we review how understanding the latent reservoir during suppressive therapy will lead to significant advances in curative approaches for HIV-1.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Reservatórios de Doenças
/
Infecções por HIV
/
HIV-1
/
Antirretrovirais
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article