Resveratrol provides neuroprotection by inhibiting phosphodiesterases and regulating the cAMP/AMPK/SIRT1 pathway after stroke in rats.

Wan, Dan; Zhou, Yehan; Wang, Ke; Hou, Yongying; Hou, Ruihang; Ye, Xiufeng

Wan, Dan; Zhou, Yehan; Wang, Ke; Hou, Yongying; Hou, Ruihang; Ye, Xiufeng.

Afiliação

Wan D; Department of Pathology, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China.
Zhou Y; Department of Pathology, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China.
Wang K; Department of Pathology, Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China.
Hou Y; Department of Pathology, Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China.
Hou R; Department of Pathology, Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China.
Ye X; Department of Pathology, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China. Electr

Brain Res Bull ; 121: 255-62, 2016 Mar.

Article em En | MEDLINE | ID: mdl-26876758

Assuntos

Encéfalo/efeitos dos fármacos; Fármacos Neuroprotetores/uso terapêutico; Diester Fosfórico Hidrolases/metabolismo; Transdução de Sinais/efeitos dos fármacos; Estilbenos/uso terapêutico; Acidente Vascular Cerebral/tratamento farmacológico; Proteínas Quinases Ativadas por AMP/genética; Proteínas Quinases Ativadas por AMP/metabolismo; Trifosfato de Adenosina/metabolismo; Animais; Encéfalo/metabolismo; Infarto Encefálico/etiologia; Infarto Encefálico/prevenção & controle; AMP Cíclico/genética; AMP Cíclico/metabolismo; Modelos Animais de Doenças; Relação Dose-Resposta a Droga; Inibidores Enzimáticos/uso terapêutico; Regulação da Expressão Gênica/efeitos dos fármacos; Masculino; Fosforilação/efeitos dos fármacos; Ratos; Ratos Sprague-Dawley; Resveratrol; Rolipram/farmacologia; Sirtuína 1/genética; Sirtuína 1/metabolismo; Acidente Vascular Cerebral/complicações; Acidente Vascular Cerebral/metabolismo

Palavras-chave

AMPK; ATP; PDEs; Resveratrol; SIRT1; Stroke

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estilbenos / Encéfalo / Transdução de Sinais / Diester Fosfórico Hidrolases / Fármacos Neuroprotetores / Acidente Vascular Cerebral Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google