[Acquired Pelger-Huët anomaly/abnormal chromatin clumping of granulocytes after allogeneic hematopoietic stem cell transplantation for acute myeloid leukaemia: medication or relapse? ]. / Anomalie de Pelger-Huët acquise/condensation anormale de la chromatine des granulocytes après allogreffe médullaire pour leucémie aiguë myéloïde : iatrogène ou signe de rechute ?
Ann Biol Clin (Paris)
; 74(1): 110-6, 2016.
Article
em Fr
| MEDLINE
| ID: mdl-26878615
ABSTRACT
An acute myeloid leukemia was diagnosed in a 53-year-old female patient. She received an allogeneic stem cell transplant. After this transplant, some neutrophils with hyposegmented nucleus and abnormal chromatin clumping appeared in the peripheral blood, and their number gradually increased. The hypothesis of early relapse after transplant was ruled out and drug-related anomaly was suspected. The authors discuss about morphological features of constitutional and acquired Pelger-Huët anomaly. In the patient reported here, ciclosporine seemed to be involved in the phenomenon, as the morphological anomaly of the neutrophils gradually decreased after the drug was discontinued.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anomalia de Pelger-Huët
/
Cromatina
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Leucemia Mieloide Aguda
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Ciclosporina
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Transplante de Células-Tronco Hematopoéticas
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Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Granulócitos
Tipo de estudo:
Diagnostic_studies
Limite:
Female
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Humans
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Middle aged
Idioma:
Fr
Ano de publicação:
2016
Tipo de documento:
Article