Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic.
EMBO J
; 35(6): 561-79, 2016 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-26888746
ABSTRACT
Phosphoinositides (PIs) form a minor class of phospholipids with crucial functions in cell physiology, ranging from cell signalling and motility to a role as signposts of compartmental membrane identity. Phosphatidylinositol 3-phosphates are present at the plasma membrane and within the endolysosomal system, where they serve as key regulators of both cell signalling and of intracellular membrane traffic. Here, we provide an overview of the metabolic pathways that regulate cellular synthesis of PI 3-phosphates at distinct intracellular sites and discuss the mechanisms by which these lipids regulate cell signalling and membrane traffic. Finally, we provide a framework for how PI 3-phosphate metabolism is integrated into the cellular network.
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Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Membrana Celular
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Fenômenos Fisiológicos Celulares
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Fosfatos de Fosfatidilinositol
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Membranas Intracelulares
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article