Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels.

Widagdo, W; Raj, V Stalin; Schipper, Debby; Kolijn, Kimberley; van Leenders, Geert J L H; Bosch, Berend J; Bensaid, Albert; Segalés, Joaquim; Baumgärtner, Wolfgang; Osterhaus, Albert D M E; Koopmans, Marion P; van den Brand, Judith M A; Haagmans, Bart L

Widagdo, W; Raj, V Stalin; Schipper, Debby; Kolijn, Kimberley; van Leenders, Geert J L H; Bosch, Berend J; Bensaid, Albert; Segalés, Joaquim; Baumgärtner, Wolfgang; Osterhaus, Albert D M E; Koopmans, Marion P; van den Brand, Judith M A; Haagmans, Bart L.

Afiliação

Widagdo W; Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Raj VS; Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Schipper D; Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Kolijn K; Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.
van Leenders GJLH; Department of Pathology, Erasmus MC, Rotterdam, The Netherlands.
Bosch BJ; Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Bensaid A; IRTA, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.
Segalés J; UAB, Centre de Recerca en Sanitat Animal (CReSA), Unitat Mixta IRTA-UAB, Campus de la Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.
Baumgärtner W; Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.
Osterhaus ADME; Department of Pathology, University of Veterinary Medicine, Hannover, Germany.
Koopmans MP; Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
van den Brand JMA; Artemis One Health, Utrecht, The Netherlands.
Haagmans BL; Center for Infection Medicine and Zoonoses Research (RIZ), University of Veterinary Medicine, Hannover, Germany.

J Virol ; 90(9): 4838-4842, 2016 May.

Article em En | MEDLINE | ID: mdl-26889022

ABSTRACT

ABSTRACT

Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor--dipeptidyl peptidase 4 (DPP4)--is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.

Assuntos

Infecções por Coronavirus/virologia; Dipeptidil Peptidase 4/genética; Regulação da Expressão Gênica; Coronavírus da Síndrome Respiratória do Oriente Médio/fisiologia; Receptores Virais/genética; Mucosa Respiratória/metabolismo; Mucosa Respiratória/virologia; Animais; Camelus; Infecções por Coronavirus/transmissão; Dipeptidil Peptidase 4/metabolismo; Humanos; Imuno-Histoquímica; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Receptores Virais/metabolismo; Replicação Viral

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Virais / Regulação da Expressão Gênica / Infecções por Coronavirus / Dipeptidil Peptidase 4 / Mucosa Respiratória / Coronavírus da Síndrome Respiratória do Oriente Médio Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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