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Generation of aggregation prone N-terminally truncated amyloid ß peptides by meprin ß depends on the sequence specificity at the cleavage site.
Schönherr, Caroline; Bien, Jessica; Isbert, Simone; Wichert, Rielana; Prox, Johannes; Altmeppen, Hermann; Kumar, Sathish; Walter, Jochen; Lichtenthaler, Stefan F; Weggen, Sascha; Glatzel, Markus; Becker-Pauly, Christoph; Pietrzik, Claus U.
Afiliação
  • Schönherr C; Institute of Pathobiochemistry, University Medical Center of the Johannes Gutenberg University of Mainz, Duesbergweg 6, 55128, Mainz, Germany.
  • Bien J; Institute of Pathobiochemistry, University Medical Center of the Johannes Gutenberg University of Mainz, Duesbergweg 6, 55128, Mainz, Germany.
  • Isbert S; Institute of Pathobiochemistry, University Medical Center of the Johannes Gutenberg University of Mainz, Duesbergweg 6, 55128, Mainz, Germany.
  • Wichert R; Institute of Biochemistry, Unit for Degradomics of the Protease Web, Christian-Albrechts-University, Otto-Hahn-Platz 9, 24118, Kiel, Germany.
  • Prox J; Institute of Biochemistry, Unit for Degradomics of the Protease Web, Christian-Albrechts-University, Otto-Hahn-Platz 9, 24118, Kiel, Germany.
  • Altmeppen H; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Kumar S; Department of Neurology, Molecular Cell Biology, University of Bonn, 53127, Bonn, Germany.
  • Walter J; Department of Neurology, Molecular Cell Biology, University of Bonn, 53127, Bonn, Germany.
  • Lichtenthaler SF; German Center for Neurodegenerative Diseases (DZNE) and Neuroproteomics, Klinikum rechts der Isar, Technische Universität München, 81675, Munich, Germany.
  • Weggen S; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  • Glatzel M; Department of Neuropathology, Heinrich Heine University, 40225, Duesseldorf, Germany.
  • Becker-Pauly C; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Pietrzik CU; Institute of Biochemistry, Unit for Degradomics of the Protease Web, Christian-Albrechts-University, Otto-Hahn-Platz 9, 24118, Kiel, Germany. cbeckerpauly@biochem.uni-kiel.de.
Mol Neurodegener ; 11: 19, 2016 Feb 19.
Article em En | MEDLINE | ID: mdl-26895626
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metaloendopeptidases / Peptídeos beta-Amiloides / Precursor de Proteína beta-Amiloide / Doença de Alzheimer / Neurônios Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metaloendopeptidases / Peptídeos beta-Amiloides / Precursor de Proteína beta-Amiloide / Doença de Alzheimer / Neurônios Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article