Pain Modulation and the Transition from Acute to Chronic Pain.
Adv Exp Med Biol
; 904: 105-15, 2016.
Article
em En
| MEDLINE
| ID: mdl-26900066
ABSTRACT
There is now increasing evidence that pathological pain states are at least in part driven by changes in the brain itself. Descending modulatory pathways are known to mediate top-down regulation of nociceptive processing, transmitting cortical and limbic influences to the dorsal horn. However, these modulatory pathways are also intimately intertwined with ascending transmission pathways through positive and negative feedback loops. Models of persistent pain that fail to include descending modulatory pathways are thus incomplete. Although teasing out individual links in a recurrent network is never straightforward, it is imperative that understanding of pain modulation be fully integrated into how we think about pain.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dor Aguda
/
Dor Crônica
/
Nociceptividade
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article